Amyloidosis

Acute

What is Amyloidosis?

Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a protein called amyloid builds up in organs. This amyloid buildup can make the organs not work properly.

  • Feeling very weak or tired.
  • Losing weight without trying.
  • Swelling in the belly, legs, ankles or feet.
  • Numbness, pain or tingling in hands or feet.
  • Skin that bruises easily.
  • Purple spots (purpura) or bruised-looking areas of skin around the eyes.
  • Heart. Amyloid reduces the heart's ability to fill with blood between heartbeats. Less blood is pumped with each beat.
  • Kidneys. Amyloid can harm the kidneys' filtering system.
  • Nervous system. Nerve damage can cause pain, numbness, or tingling of the fingers and feet.

Usually, an excess amount of antibody protein is produced and the abnormal light chain portion or the whole antibody molecule accumulates in the body tissues in the form of amyloid deposits. AA amyloidosis is caused by the inflammatory disease process that is part of the underlying disease.

Some forms of amyloidosis are more likely to strike people living with infections or other conditions that cause chronic inflammation. People receiving long-term kidney dialysis are at risk for developing one type of amyloidosis, but modern dialysis techniques are making this less likely.

Most types of amyloidosis are not preventable, but managing your kidney disease may help you delay or avoid kidney failure. You may be able to prevent AA amyloidosis if your chronic inflammatory condition is treated early and the inflammation is kept under control.

How is it diagnosed?

How is it diagnosed?

During treatment for amyloidosis, chemotherapy is used to destroy abnormal cells in the blood. Common ways to give chemotherapy include an intravenous (IV) tube placed into a vein using a needle, a shot under the skin, or a pill or capsule that is swallowed (orally).

How is it treated?

Treatment for acute myeloid leukemia is vital. It varies with the patient and stage of the disease. Treatment options include

A bone marrow transplant is a medical procedure in which the bone marrow that contains the plasma cells that produce amyloid protein are destroyed by high doses of chemotherapy and then replaced by highly specialized cells.

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