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Bullous Pemphigoid

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Acute

What is Bullous Pemphigoid?

Bullous pemphigoid (BUL-us PEM-fih-goid) is a rare skin condition that causes large, fluid-filled blisters. They develop on areas of skin that often flex — such as the lower abdomen, upper thighs or armpits. Bullous pemphigoid is most common in older adults.

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The signs and symptoms of bullous pemphigoid may include: Itching skin, weeks or months before blisters form. Large blisters that don't easily rupture when touched, often along creases or folds in the skin. Skin around the blisters that is normal, reddish or darker than normal.

  • Bacterial staphylococcal and streptococcal skin infection, and sepsis.
  • Viral infection with herpes simplex, varicella, or herpes zoster.
  • Complications of treatment.
  • Underlying and associated diseases.

Bullous pemphigoid is caused by a problem with the immune system (the body's defence against infection). Instead of attacking germs, it attacks and damages the skin. It's not known why this happens. Sometimes it's been linked to skin damage (such as sunburn) or taking certain medicines.

If you have blisters in your mouth, avoid eating hard and crunchy foods, such as chips and raw fruits and vegetables, because these types of foods might aggravate symptoms.

Ultraviolet light therapy to treat certain skin conditions may trigger bullous pemphigoid, as can radiation therapy to treat cancer. Medical conditions. Disorders that may trigger bullous pemphigoid include psoriasis, lichen planus, diabetes, rheumatoid arthritis, ulcerative colitis and multiple sclerosis.

How is it diagnosed?

How is it diagnosed?

The most common treatment is prednisone, which comes in pill form. But long-term use can increase your risk of weak bones, diabetes, high blood pressure, high cholesterol and infection. Corticosteroid ointment can be rubbed on your affected skin and causes fewer side effects.

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How is it treated?

Treatment for acute myeloid leukemia is vital. It varies with the patient and stage of the disease. Treatment options include

If bullous pemphigoid is suspected, skin biopsy is done for histology and direct immunofluorescence testing. Samples from in and around the lesion itself are often used for histology, but samples of uninvolved skin (often about 3 mm from the edge of a lesion) are used for direct immunofluorescence.

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