Hemophilia

Symptoms

There are a number of symptoms of Hemophilia, which may include

Unexplained and excessive bleeding from cuts or injuries, or after surgery or dental work.
Many large or deep bruises.
Unusual bleeding after vaccinations.
Pain, swelling or tightness in your joints.
Blood in your urine or stool.
Nosebleeds without a known cause.
In infants, unexplained irritability.

Complications

Bleeding within joints that can lead to chronic joint disease and pain.
Bleeding in the head and sometimes in the brain which can cause long term problems, such as seizures and paralysis.
Death can occur if the bleeding cannot be stopped or if it occurs in a vital organ such as the brain.

Causes

Hemophilia is caused by a mutation or change, in one of the genes, that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or mutation can prevent the clotting protein from working properly or to be missing altogether.

Risk factors

To develop severe hemophilia C, a person must have parents who both carry the genetic mutation. A person can inherit the condition from just one parent, but it's usually less severe when a patient inherits only one mutated gene.

Prevention

Because the condition is genetic, there's no way to prevent hemophilia. However, patients can take steps to limit the frequency and severity of their bleeding. Aspirin and NSAIDs (ibuprofen and similar drugs) can worsen bleeding in patients with hemophilia.

How is it treated?

Treatment for acute myeloid leukemia is vital. It varies with the patient and stage of the disease. Treatment options include

The main treatment for severe hemophilia involves replacing the clotting factor you need through a tube in a vein. This replacement therapy can be given to treat a bleeding episode in progress. It can also be given on a regular schedule at home to help prevent bleeding episodes.

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