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Immunoglobulin D Deficiency

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Acute

What is Immunoglobulin D Deficiency?

Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins. Little is known about the normal function of IgD, and few clinical signs or symptoms are associated with its absence

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Selective IgD deficiency has no known symptoms and does not increase the risk of infection if it occurs without other Ig deficiencies. The cause of IgD deficiency is usually genetic in origin.

In the study group, a number of the individuals with low IgD had rheumatologic disease (eg, juvenile rheumatoid arthritis, lupus, psoriatic arthritis, vasculitis), but the frequency of low IgD within groups of patients with each disease did not differ from the normal controls using chi-square analysis.

Low serum IgD levels are not distributed in a normal gaussian fashion. IgD deficiency is associated with the specific human leukocyte antigens HLA-B18, F1C30, and DR3 in a Spanish Basque population and HLA-B8, SC01, DR3 in white subjects in an American study.

Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins. Little is known about the normal function of IgD, and few clinical signs or symptoms are associated with its absence.

Immunoglobulin (Ig) replacement therapy is the standard treatment for individuals with antibody deficiencies. Ig is given intravenously (IVIG) or subcutaneously (SCIG) and replaces the antibodies a person should be making.

How is it diagnosed?

How is it diagnosed?

Antibody deficiency disorders have a better prognosis if they can be treated with intravenous immunoglobulins (IVIG) or subcutaneous infusions once a week. The use of broad-spectrum antibiotics can improve life expectancy.

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How is it treated?

Treatment for acute myeloid leukemia is vital. It varies with the patient and stage of the disease. Treatment options include

IgD. Immunoglobulin D (IgD) is primarily found on the surface of B lymphocytes where it functions as a receptor for antigen. IgD does not bind complement or cells through the Fc receptor. A small amount of IgD is secreted accounting for about 0.25 per cent of the total serum immunoglobulins (Vladutiu, 2000).

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