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Osteocalcin

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osteocalcin

What is Osteocalcin?

A 49-amino acid calcium-binding peptide secreted by mature osteoblasts, is the most abundant non-collagen protein found in bone [17,22]. Most OC secreted by osteoblasts is incorporated into the organic matrix that will later ossify into bone, however, a small fraction is secreted into the circulation.

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Bones that break more easily, particularly those in the hips, lower back and feet. difficulty walking and a change in how you walk – possibly with a waddle. muscle cramps. pins and needles in the hands and feet because of low calcium levels.

Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition, and male fertility.

In the pancreas, osteocalcin causes an increase in β-cell proliferation as well as increased insulin production. Additional studies have suggested that osteoclacin acts in the brain to stimulate neurotransmitter production and in the testes to increase testosterone production.

Evidence for a role of carboxylated osteocalcin in bone health. There has been long-standing interest in the potential role of vitamin K in the prevention of osteoporotic fractures based on its role in carboxylation of osteocalcin.

Furthermore, our present study suggested that serum osteocalcin levels were associated with multiple cardiovascular risk factors according to age and sex, including overweight/obesity, high HbA1C, high FBG, high TG, MetS, and LDL-C, after adjusting for potential confounding variables.

How is it diagnosed?

How is it diagnosed?

Physical exercise can significantly increase the levels of osteocalcin. In Pernambuco et al. (2013) study, an 8-months aquatic aerobic exercise program is effective in increasing circulating osteocalcin levels in post-menopausal women with low bone mineral density (Pernambuco et al., 2013).

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How is it treated?

Treatment for acute myeloid leukemia is vital. It varies with the patient and stage of the disease. Treatment options include

Blood sample is collected for osteocalcin blood test. A band is wrapped around the arm, 3-4 inches above the site of collection. The collection site is usually the superficial vein that lies within the elbow pit. The site will be cleared with 70% alcohol in an outward spiral, away from the site of needle injection.

 

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