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Cushing’s Syndrome

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Cushing’s Syndrome

What is Cushing’s Syndrome?

Too much cortisol can cause some of the main symptoms of Cushing syndrome — a fatty hump between the shoulders, a rounded face, and pink or purple stretch marks on the skin. Cushing syndrome also can cause high blood pressure or bone loss. Sometimes, it can cause type 2 diabetes.

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How is Cushing’s Syndrome treatment done?

If an ACTH-producing tumor isn't found, or if one can't be fully removed and Cushing syndrome continues, your health care provider may recommend removing the adrenal glands. This is called a bilateral adrenalectomy. This procedure immediately stops the body from making too much cortisol.

Before surgery, medications that inhibit adrenal enzymes (ketoconazole or metyrapone) can lower cortisol levels. After surgery, daily adrenal hormone replacement is usually necessary. (See "Patient education: Adrenal insufficiency (Beyond the Basics)", section on 'Hormone deficiencies'.)

After Cushing syndrome surgery, your body won't make enough ACTH. You'll need to take a cortisol replacement medicine to give your body the right amount of cortisol. Most of the time, your body starts making enough cortisol again, and your health care provider can taper off the replacement medicine

What are the benefits of Cushing’s Syndrome Treatment?

Children with Cushing's syndrome tend to have obesity and grow more slowly than other children. Women may have excess hair on their face, neck, chest, abdomen, and thighs. Menstrual periods may become irregular or stop. Men may have decreased fertility with lowered interest in sex and may have erectile dysfunction.

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